What question did this study set out to answer?

This research aims to investigate how chemoreceptor stimulation influences sympathetic nerve activity during different respiratory phases.

November 1, 1989AJP Regulatory Integrative and Comparative Physiology

Chemoreceptor stimulation on sympathetic activity: dependence on respiratory phase

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Population

Chloralose-anesthetized, vagotomized, paralyzed, and artificially ventilated cats breathing 100% O2 (n=8)

Design

Preclinical

Authors

PKPéter KatonaHungarian School Sport Federation KDKlaus DembowskyHohenstein Institute JCJ. CzachurskiHeidelberg University

Discussion

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Implication

Phase-dependent cardiac sympathetic responses in this cat model; leaves open translation to human cardiorespiratory disease or clinical chemoreflex modulation.

Key Points

This research aims to investigate how chemoreceptor stimulation influences sympathetic nerve activity during different respiratory phases.
Performed experiments on chloralose-anesthetized, vagotomized, and paralyzed cats
Stimulated peripheral chemoreceptors with CO2-saturated NaHCO3 injections during varied respiratory phases
Measured responses in cardiac and renal sympathetic nerves using digital integration
Cardiac nerve responses to chemoreceptor stimulation peaked during late inspiration and were minimal during postinspiration and early expiration
Renal nerve responses showed phase dependence in only 25% of observed cases
Increased end-tidal CO2 levels enhanced overall sympathetic activity modulation but reduced responses to chemoreceptor stimulation

Structured PICO

Population

Chloralose-anesthetized, vagotomized, paralyzed, and artificially ventilated cats breathing 100% O2 (n=8)

Intervention

Peripheral chemoreceptor stimulation by rapid injections of CO2-saturated NaHCO3 in different phases of the respiratory cycle

Outcome

Responses of cardiac and renal sympathetic nerves computed by digital integrationsurrogate

In an animal model, the respiratory modulation of chemoreceptor-induced sympathetic responses was less prominent than the modulation of spontaneous activity, suggesting phase dependence is driven by spontaneous expiratory diminution of sympathetic activity.

Cite This Study

Katona et al. (1989) studied this question.

synapsesocial.com/papers/6a7ca984e6f41aaf0bcf8291 https://doi.org/10.1152/ajpregu.1989.257.5.r1027

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Implication

Phase-dependent cardiac sympathetic responses in this cat model; leaves open translation to human cardiorespiratory disease or clinical chemoreflex modulation.

Chemoreceptor stimulation on sympathetic activity: dependence on respiratory phase

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chemoreceptor stimulation on sympathetic activity: dependence on respiratory phase

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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