Why the study?
Does metabolic acidosis alter the activity of aortic and carotid chemoreceptor afferents in cats?
Population
12 cats anesthetized with alpha-chloralose, paralyzed, and artificially ventilated.
Comparison
Slow injection of 1 M lactic acid in an average… vs Baseline activity before injection.
Design
Preclinical
Authors
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Aortic chemoreceptor responses to acidosis remain limited to feline models; leaves open translational relevance to human ventilatory control.
Does metabolic acidosis alter the activity of aortic and carotid chemoreceptor afferents in cats?
Metabolic acidosis increases aortic chemoreceptor activity and enhances responses to hypoxia and hypercapnia in cats, though to a lesser extent than in carotid chemoreceptors.
Pokorski et al. (1983) studied this question.
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