July 1, 1982Journal of Applied Physiology

Inhibition of aortic chemoreceptor responses by metabolic alkalosis in the cat

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Why the study?

Does metabolic alkalosis inhibit aortic chemoreceptor responses to hypoxia and hypercapnia in anesthetized cats?

Population

12 anesthetized cats

Comparison

Metabolic alkalosis induced by intravenous… vs Baseline responses before induction of metabolic…

Design

Preclinical

Authors

MPMieczysław PokorskiUniversity of Opole SLS. LahiriAll India Institute of Hygiene and Public Health

Discussion

Member takes

Implication

Metabolic alkalosis effects on chemoreceptors warrant no clinical pH adjustments; leaves open translation to human ventilatory control.

Structured PICO

Does metabolic alkalosis inhibit aortic chemoreceptor responses to hypoxia and hypercapnia in anesthetized cats?

Population

12 anesthetized cats

Intervention

Metabolic alkalosis induced by intravenous administration of sodium bicarbonate (average dose 7 mmol/kg)

Comparator

Baseline responses before induction of metabolic alkalosis

Outcome

Aortic chemoreceptor activity in response to steady-state isocapnic hypoxia and hypercapnia on hyperoxiasurrogate

Metabolic alkalosis inhibits aortic chemoreceptor responses to hypoxia and hypercapnia, indicating that the major effect of CO2 on these receptors is mediated by hydrogen ion concentration.

Cite This Study

Pokorski et al. (1982) studied this question.

synapsesocial.com/papers/6a89cf48712e087af392ce40 https://doi.org/10.1152/jappl.1982.53.1.75

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Inhibition of aortic chemoreceptor responses by metabolic alkalosis in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of aortic chemoreceptor responses by metabolic alkalosis in the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider