Why the study?
Does intravenous KCl infusion alter the steady-state discharge of carotid body chemoreceptors under varying oxygen and carbon dioxide levels in anesthetized cats?
Population
Pentobarbitone-anaesthetized cats
Comparison
Intravenous infusions of 0.1 mmol/min KCl under… vs Baseline or control discharge frequencies…
Design
Preclinical
Authors
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Caution against clinical extrapolation of KCl effects; hypothesis-generating for potassium in human hypoxic chemoreflexes.
Does intravenous KCl infusion alter the steady-state discharge of carotid body chemoreceptors under varying oxygen and carbon dioxide levels in anesthetized cats?
Intravenous potassium infusion excites carotid body chemoreceptors in cats, an effect enhanced by hypoxia and abolished by hyperoxia, suggesting extracellular potassium may mediate hypoxic excitation.
Burger et al. (1988) studied this question.
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