Key result
The response of aortic chemoreceptors to a CO2 stimulus was a fraction of that of carotid chemoreceptors, and the response to hypoxia was relatively blunted.
Aortic chemoreceptors exhibit a blunted response to hypoxia and CO2 compared to carotid chemoreceptors, suggesting that their low CO2 response is responsible for the blunted hypoxic response.
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Attenuated aortic chemoreceptor responses in cats warrant caution extrapolating to humans; leaves open distinct sensor roles in cardiorespiratory control.
A quantitative comparison of the responses between aortic and carotid chemoreceptors to steady-state levels of arterial CO2 and O2 partial pressure was made in 35 cats anesthetized, paralyzed, and artificially ventilated. The measurements on the two receptors were made simultaneously in 6 cats and separately in 29 cats. The response of aortic chemoreceptors to a CO2 stimulus was a fraction of that of carotid chemoreceptors, and the response to hypoxia was relatively blunted. The differences between the two chemoreceptors are quantitative rather than qualitative. Since a low arterial CO2 partial pressure stimulus is known to attenuate the hypoxic response of carotid chemoreceptors, it is suggested that the low CO2 response of aortic body chemoreceptors is responsible for their blunted hypoxic response.
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Lahiri et al. (1981) studied this question. Aortic chemoreceptors vs. Carotid chemoreceptors was evaluated on Responses to steady-state levels of arterial CO2 and O2 partial pressure. The response of aortic chemoreceptors to a CO2 stimulus was a fraction of that of carotid chemoreceptors, and the response to hypoxia was relatively blunted.
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