April 1, 1990Cell Biology International Reports

Acidosis, cardiac stunning and its prevention by oxygen

View Full Paper

Ask AI

Bookmark

Population

Rat Langendorff heart model, paced at 5 Hz, under constant aortic pressure of 8.3 kPa

Comparison

Inclusion of fluorocarbon in the perfusion media… vs Perfusion at pH 7.0 without fluorocarbon

Design

Preclinical

Follow-up

10 minutes

Authors

WHW.C. HülsmannErasmus University Rotterdam LDL. DewitErasmus MC Cancer Institute

Discussion

Member takes

Implication

Hypothesis-generating for fluorocarbon oxygen delivery in acidotic hearts; leaves open in vivo or clinical relevance.

Structured PICO

Population

Rat Langendorff heart model, paced at 5 Hz, under constant aortic pressure of 8.3 kPa

Intervention

Inclusion of fluorocarbon (an O2 vehicle) in the perfusion media during pH 7.0 perfusion

Comparator

Perfusion at pH 7.0 without fluorocarbon

Outcome

Cardiac contractility and tissue anaerobiosis (loss of high-energy phosphates, accumulation of lactate and glycerol-3-phosphate)surrogate

In a rat Langendorff heart model, acidosis-induced cardiac stunning and tissue anaerobiosis can be prevented by enhancing oxygen delivery with fluorocarbon.

Cite This Study

Hülsmann et al. (1990) studied this question.

synapsesocial.com/papers/6a7d40b72935e92dbc775f06 https://doi.org/10.1016/0309-1651(90)91200-n

View Full Paper

Ask AI

Bookmark

Acidosis, cardiac stunning and its prevention by oxygen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acidosis, cardiac stunning and its prevention by oxygen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider