September 1, 1991AJP Heart and Circulatory Physiology
Influence of metabolic substrate on rat heart function and metabolism at different coronary flows
Why the study?
Does hexanoate perfusion alter contractile strength and myocardial oxygen consumption compared to glucose in isolated rat hearts?
Population
Isovolumically contracting isolated rat hearts
Comparison
Perfusion with solutions containing hexanoate vs Perfusion with solutions containing glucose
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hexanoate may compromise efficiency in low-flow states; animal data leaves open translation to human substrate selection.
Structured PICO
Does hexanoate perfusion alter contractile strength and myocardial oxygen consumption compared to glucose in isolated rat hearts?
P
Population
Isovolumically contracting isolated rat hearts
I
Intervention
Perfusion with solutions containing hexanoate
C
Comparator
Perfusion with solutions containing glucose
O
Outcome
Contractile strength, myocardial oxygen consumption (MVO2), high- and low-energy phosphate levels, and intracellular pHsurrogate
In isolated rat hearts, hexanoate perfusion decreases myocardial efficiency compared to glucose by increasing non-work-related oxygen demands, particularly at low coronary flows.
Cite This Study
Burkhoff et al. (1991) studied this question.