Why the study?
Does changing blood CO2 level affect coronary flow and myocardial oxygen consumption in open-chested anesthetized dogs?
Population
Open-chested, anesthetized dogs
Comparison
Hypo- and hypercapnia induced by changing the… vs Normocapnia/baseline
Design
Preclinical
Authors
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Hypercapnia may augment coronary flow relative to effort in dogs; leaves open relevance to human myocardial energetics.
Does changing blood CO2 level affect coronary flow and myocardial oxygen consumption in open-chested anesthetized dogs?
Hypercapnia increases coronary blood flow relative to cardiac effort without altering myocardial oxygen consumption in a canine model.
Feinberg et al. (1960) studied this question.
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