Why the study?
Does hypoxia compared to hyperoxia modulate sympathetic and cardiovascular responses during hypercapnia in conscious humans?
Population
7 conscious human subjects
Comparison
CO2 rebreathe protocol elevating end tidal CO2… vs CO2 rebreathe protocol with end tidal oxygen…
Design
Other
Authors
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Hypoxia may augment hypercapnic cardiac output responses; hypothesis-generating for chemoreflex modulation and requires prospective confirmation before clinical consideration.
Does hypoxia compared to hyperoxia modulate sympathetic and cardiovascular responses during hypercapnia in conscious humans?
Peripheral chemoreceptors exert an important influence over cardiovascular reflex responses to hypercapnia, with hypoxic hypercapnia shifting the dose-response effect of PET(CO2) to the left.
Shoemaker et al. (2002) studied this question.
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