Key result
Abdominal aorto-caval shunting selectively reduces subendocardial oxygen consumption, primarily in the apical myocardium.
Why the study?
The effects of a moderate arterio-venous shunt on regional oxygen supply and consumption in the left ventricle were not well characterized.
Does a moderate arterio-venous shunt alter regional oxygen extraction, blood flow, and oxygen consumption in the dog heart?
Comparison
Abdominal aorto-caval shunt vs control (no shunt)
Design
Preclinical experimental study
Authors
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Hypothesis-generating in canine models; leaves open applicability to human cardiovascular conditions involving AV shunts.
Does a moderate arterio-venous shunt alter regional oxygen extraction, blood flow, and oxygen consumption in the dog heart?
A moderate arterio-venous shunt alters regional myocardial oxygen dynamics, specifically reducing subendocardial oxygen consumption and abolishing transmural gradients.
Briden et al. (1981) studied this question. Abdominal aorto-caval shunt vs. Control (no shunt) was evaluated on Regional oxygen extraction, coronary blood flow, and oxygen consumption. An abdominal aorto-caval shunt reduced subendocardial oxygen consumption, especially in the apex, without reducing subepicardial oxygen consumption in dogs.
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