Why the study?
Does changing cardiac output affect intrapulmonary shunt in a dog model of hemorrhagic pulmonary edema?
Population
17 alpha-chloralose-anesthetized dogs with hemorrhagic pulmonary edema induced by intravenous oleic acid
Design
Preclinical
Authors
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May warrant accounting for cardiac output when interpreting shunt in lung injury; hypothesis-generating for human translation.
Does changing cardiac output affect intrapulmonary shunt in a dog model of hemorrhagic pulmonary edema?
Changes in intrapulmonary shunt in the setting of diffuse lung injury must be interpreted in light of changes in cardiac output, as shunt fraction correlates linearly with cardiac output.
Lynch et al. (1979) studied this question.
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