December 1, 1991Journal of Applied Physiology

Relationship among cardiac output, shunt, and inspired O2 concentration

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Population

6 methacholine-challenged mongrel dogs

Design

Preclinical

Follow-up

approximately 90 min

Authors

PWPeter D. WagnerUniversity of Nebraska–Lincoln WSW. SchaffartzikUniversity Medical Center RPRenato PredilettoUniversity of Pisa

Discussion

Member takes

Implication

FiO2 modulates shunt response to cardiac output in this canine model; leaves open translation to human hypoxemic respiratory failure.

Structured PICO

Population

6 methacholine-challenged mongrel dogs

Intervention

Breathing 100% O2 (n=2), room air (n=2), or 12% O2 (n=2) while cardiac output was altered several times by sequentially opening and closing arteriovenous fistulas every 10 min for approximately 90 min after a standard methacholine challenge

Outcome

Dependence of combined shunt and low ventilation-perfusion (VA/Q) blood flow on cardiac outputsurrogate

The FIO2-dependent behavior of the shunt-cardiac output relationship suggests that the increase in shunt with cardiac output depends more on vascular tone of noninjured areas than on tone of the low VA/Q regions.

Cite This Study

Wagner et al. (1991) studied this question.

synapsesocial.com/papers/6a23e9c698edd3e1959eea2e https://doi.org/10.1152/jappl.1991.71.6.2191

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Relationship among cardiac output, shunt, and inspired O2 concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship among cardiac output, shunt, and inspired O2 concentration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider