Key result
In dogs, increasing pulmonary blood flow increased venous admixture during room air ventilation, while increasing mixed venous PO2 decreased venous admixture.
Population
Dogs with normal lungs and dogs with oleic-acid-induced pulmonary edema
Comparison
Independent alteration of mixed venous O2… vs Constant PVO2 or constant Qt
Design
Preclinical
Authors
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Animal data advise against clinical extrapolation of shunt physiology; leaves open interactions of pulmonary blood flow and mixed venous PO2 with venous admixture.
In a canine model, increases in pulmonary blood flow increase venous admixture during room air ventilation, while increases in mixed venous O2 tension decrease it; however, in edematous lungs, increases in either parameter increase shunt.
Bishop et al. (1983) studied Normal lungs and oleic-acid-induced pulmonary edema. Alteration of mixed venous PO2 and pulmonary blood flow vs. Constant PVO2 or constant pulmonary blood flow was evaluated on Venous admixture and intrapulmonary shunt. In dogs, increasing pulmonary blood flow increased venous admixture during room air ventilation, while increasing mixed venous PO2 decreased venous admixture.
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