Population
Isolated blood-perfused canine left lower lobes with edema
Comparison
Changes in mixed venous PO2 and blood flow vs Baseline PvO2 and constant blood flow (QT)
Design
Preclinical
Authors
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Higher PvO2 increases shunt in edematous lungs independent of flow; leaves open clinical relevance and requires human validation.
In isolated canine lung lobes with edema, changes in mixed venous PO2, but not blood flow rate, independently influence shunt fraction.
Sandoval et al. (1983) studied this question.
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