Why the study?
Does PEEP improve gas exchange and pulmonary perfusion in a canine model of lobar pneumonia?
Population
10 dogs with left lower lobe (LLL) pneumonia (6 closed-chest, 4 open-chest)
Comparison
Positive end-expiratory pressure while breathing… vs Baseline and after PEEP
Design
Preclinical
Authors
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Slight gas exchange gains with PEEP in canine lobar pneumonia; hypothesis-generating for perfusion-dependent effects and requires human validation.
Does PEEP improve gas exchange and pulmonary perfusion in a canine model of lobar pneumonia?
In a canine model of lobar pneumonia, PEEP alters regional perfusion and shunt, resulting in slight overall improvements in gas exchange that depend on the relative magnitude of regional changes.
Mink et al. (1981) studied this question.
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