Why the study?
Does positive end-expiratory pressure (PEEP) affect extravascular lung water and central blood volume in mechanically ventilated dogs?
Population
24 mongrel dogs, anaesthetized and ventilated mechanically in the supine position
Comparison
Positive end-expiratory pressure of 1.0 kPa for… vs Zero end-expiratory pressure for 8 h, or 15 min…
Design
Preclinical
Follow-up
Up to 8 hours
Authors
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Hypothesis-generating for PEEP duration effects on lung water; should not yet change clinical ventilation practices.
Does positive end-expiratory pressure (PEEP) affect extravascular lung water and central blood volume in mechanically ventilated dogs?
Prolonged application of PEEP (8 hours) in mechanically ventilated dogs significantly increases extravascular lung water, whereas short-term application does not.
Frostell et al. (1987) studied this question.
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