Why the study?
Does regional and whole-lung PEEP alter the partitioning of blood flow between hypoxic and normoxic lung compartments in dogs?
Population
Open-chested (Group I) and closed-chested (Group II) dogs
Design
Preclinical
Authors
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Does not support altering clinical PEEP strategies; hypothesis-generating for regional hypoxic-normoxic interactions and requires human validation.
Does regional and whole-lung PEEP alter the partitioning of blood flow between hypoxic and normoxic lung compartments in dogs?
In a dog model, the effect of PEEP on diseased lung is a summation of its beneficial and deleterious regional effects on blood flow partitioning between hypoxic and normoxic compartments.
Benumof et al. (1979) studied this question.
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