Key result
In the systemic circulation, the venous-to-arterial compliance ratio increased from 9.3 to 21.9 during step reductions in flow (P<0.001), while vascular resistance was independent of flow.
Population
12 pentobarbital-anesthetized dogs with sinus denervation and vagotomy
Comparison
Step reductions in flow from baseline to zero… vs Baseline flow
Design
Preclinical
Authors
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Flow-dependent systemic compliance ratio is hypothesis-generating; should not yet influence clinical vascular assessments or modeling assumptions.
p-value: p=<0.001
This preclinical study demonstrates that venous-to-arterial compliance ratio in the systemic circulation is highly dependent on flow, whereas it remains constant in the pulmonary circulation.
Chen et al. (1991) studied this question. Step reductions in flow (Q) vs. Baseline flow was evaluated on Venous-to-arterial compliance ratio (Cv/Ca) and vascular resistance (VR) (p=<0.001). In the systemic circulation, the venous-to-arterial compliance ratio increased from 9.3 to 21.9 during step reductions in flow (P<0.001), while vascular resistance was independent of flow.
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