What question did this study set out to answer?

To determine how selective and combined autonomic nervous system antagonists alter the multipoint pulmonary vascular pressure-cardiac index relationship in conscious dogs during normoxia.

June 1, 1986Journal of Applied Physiology

Neural antagonists modulate pulmonary vascular pressure-flow plots in conscious dogs

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Why the study?

Does autonomic nervous system blockade modulate pulmonary vascular pressure-flow plots in conscious dogs?

Population

conscious dogs during normoxia

Comparison

total autonomic ganglionic block, cholinergic… vs autonomic nervous system (ANS) intact

Design

Preclinical

Authors

PMPaul A. MurrayCleveland State University RLRobert F. LodatoThe University of Texas Health Science Center at Houston JMJ. R. MichaelJohns Hopkins University

Discussion

Member takes

Implication

Net pulmonary vasodilatory ANS effect in normoxic dogs does not alter clinical practice; leaves open translation to human pulmonary hemodynamics.

Key Points

To determine how selective and combined autonomic nervous system antagonists alter the multipoint pulmonary vascular pressure-cardiac index relationship in conscious dogs during normoxia.
Generated multipoint pulmonary vascular pressure-cardiac index (P/Q) plots in conscious dogs during normoxia by graded constriction of the thoracic inferior vena cava.
Evaluated hemodynamics with the autonomic nervous system intact and following total autonomic ganglionic block, cholinergic block, and alpha- and beta-adrenergic block alone and in combination.
Total ganglionic block, beta-adrenergic block, and combined alpha- and beta-adrenergic block consistently increased the pulmonary vascular pressure gradient (PAP-PCWP) across flow rates from 60 to 140 ml·min⁻¹·kg⁻¹.
Alpha-adrenergic block decreased PAP-PCWP across all cardiac index levels, while cholinergic block caused minor divergent effects at flow extremes, indicating that basal autonomic tone promotes net pulmonary vasodilatation.

Structured PICO

Does autonomic nervous system blockade modulate pulmonary vascular pressure-flow plots in conscious dogs?

Population

conscious dogs during normoxia

Intervention

total autonomic ganglionic block, cholinergic block, and sympathetic alpha- and beta-adrenergic block alone and in combination

Comparator

autonomic nervous system (ANS) intact

Outcome

pulmonary vascular pressure gradient (pulmonary arterial pressure [PAP] - pulmonary capillary wedge pressure [PCWP]) across a range of cardiac index (Q)surrogate

The autonomic nervous system exerts an active regulatory influence on the pulmonary vascular pressure-flow relationship in conscious dogs, with a net effect of pulmonary vasodilatation during normoxia.

Cite This Study

Murray et al. (1986) studied this question.

synapsesocial.com/papers/6a8798d786c445008eca805b https://doi.org/10.1152/jappl.1986.60.6.1900

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Implication

Net pulmonary vasodilatory ANS effect in normoxic dogs does not alter clinical practice; leaves open translation to human pulmonary hemodynamics.

Neural antagonists modulate pulmonary vascular pressure-flow plots in conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Neural antagonists modulate pulmonary vascular pressure-flow plots in conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider