What question did this study set out to answer?

To assess the net effect of pentobarbital sodium anesthesia on baseline pulmonary vascular pressure-to-cardiac index relationships and determine whether autonomic nervous system regulation of pulmonary hemodynamics is altered.

May 1, 1989AJP Heart and Circulatory Physiology

Pentobarbital anesthesia alters pulmonary vascular response to neural antagonists

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Authors

DNDaniel NyhanJohns Hopkins University HGH. M. GollJohns Hopkins University BCB. B. ChenJohns Hopkins University

Discussion

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Implication

Pentobarbital alters ANS regulation of canine pulmonary P/Q; leaves open translation to human anesthesia or clinical hemodynamics.

Key Points

To assess the net effect of pentobarbital sodium anesthesia on baseline pulmonary vascular pressure-to-cardiac index relationships and determine whether autonomic nervous system regulation of pulmonary hemodynamics is altered.
Assessed pulmonary vascular pressure-to-cardiac index (P/Q) relationships in conscious and anesthetized dogs by graded constriction of the thoracic inferior vena cava to decrease cardiac output.
Administered intravenous pentobarbital sodium (30 mg/kg) and evaluated responses to autonomic antagonists, including prazosin (alpha-blocker), propranolol (beta-blocker), and atropine (cholinergic blocker).
Pentobarbital anesthesia had no net effect on the baseline pulmonary vascular P/Q relationship compared with conscious dogs.
Alpha-adrenergic blockade with prazosin caused active pulmonary vasodilation (P < 0.01) in conscious dogs but active vasoconstriction (P < 0.01) during pentobarbital anesthesia.
Cholinergic blockade with atropine caused vasodilation (P < 0.01) in conscious dogs versus vasoconstriction (P < 0.01) under pentobarbital, while beta-adrenergic-induced vasoconstriction via propranolol (P < 0.01) was significantly attenuated (P < 0.05) under anesthesia.

Cite This Study

Nyhan et al. (1989) studied this question.

synapsesocial.com/papers/6a951b6c8ce716a7e9fa6238 https://doi.org/10.1152/ajpheart.1989.256.5.h1384

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Pentobarbital anesthesia alters pulmonary vascular response to neural antagonists

Discussion

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Implication

Key Points

Cite This Study

Pentobarbital anesthesia alters pulmonary vascular response to neural antagonists

Discussion

Member takes

Implication

Key Points

Cite This Study

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