Population
6 dogs implanted with chronic arterial and venous catheters
Comparison
Pentobarbital anesthesia and graded hemorrhage… vs Unanesthetized state (conscious control)
Design
Preclinical
Follow-up
1.5 hours
Authors
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Alerts researchers to anesthesia effects on PRA in dogs; leaves open translation to conscious states or humans.
Pentobarbital anesthesia rapidly increases plasma renin activity in dogs, while hemorrhage-induced increases in conscious dogs occur independently of arterial baroreceptor mechanisms.
Johnson et al. (1975) studied this question.
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