Why the study?
Does pentobarbital anesthesia affect the baroreflex arterial pressure control system in rabbits over time?
Population
Rabbits with chronically in-dwelt catheters in the aortic arch via the left subclavian and left common…
Comparison
Intravenous injection of sodium pentobarbital in… vs Conscious state (preanesthetic level)
Design
Preclinical
Follow-up
77-98 minutes after anesthesia
Authors
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Transient baroreflex suppression by pentobarbital in rabbits warrants caution in acute experiments; leaves open translation to other species or anesthetics.
Does pentobarbital anesthesia affect the baroreflex arterial pressure control system in rabbits over time?
Pentobarbital sodium exerts a time-dependent inhibitory effect on the baroreflex system in rabbits, which recovers by 70 minutes post-administration.
Katsuda et al. (2000) studied this question.
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