Key result
Pentobarbital anesthesia fails to alter arterial pressure fall after hemorrhage versus the conscious state.
Why the study?
The effect of pentobarbital anesthesia on the rapidly acting arterial pressure control system after hemorrhage was unclear.
Does pentobarbital anesthesia affect arterial pressure fall after 10% hemorrhage in splenectomized dogs?
Population
Splenectomized dogs chronically instrumented for pressure and flow measurement
Comparison
Pentobarbital anesthesia (30 mg/kg) vs conscious state
Design
Preclinical experimental study with nerve denervation conditions
Follow-up
1-2 minutes after 10% hemorrhage
Authors
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Pentobarbital suitable for canine hemorrhage models; leaves open translation to conscious humans or other species.
Does pentobarbital anesthesia affect arterial pressure fall after 10% hemorrhage in splenectomized dogs?
Absolute Event Rate: 9.4% vs 8%
p-value: p=not significant
Pentobarbital anesthesia has little effect on the rapidly acting arterial pressure control system's capacity to restore mean arterial pressure after a brief 10% hemorrhage in dogs.
Hosomi et al. (1979) studied 10% hemorrhage. Pentobarbital anesthesia vs. Conscious state was evaluated on Arterial pressure fall (delta AP) at 1-2 min after hemorrhage (p=not significant). Pentobarbital anesthesia did not significantly alter the arterial pressure fall 1-2 minutes after a 10% hemorrhage compared to the conscious state (9.4 vs 8.0 mmHg).
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