What question did this study set out to answer?

To determine the initial effects of pentobarbital on autonomic efferent and afferent discharge rates and cardiovascular dynamics in dogs with and without endotoxemia.

October 1, 1978Acta Physiologica Scandinavica

Suppression of autonomic postganglionic discharges by pentobarbital in dogs, with or without endotoxemia

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Why the study?

Does pentobarbital affect autonomic efferent and afferent discharge rates in dogs with or without endotoxemia?

Population

26 dogs under morphine-chloralose anesthesia, half given endotoxin E. coli (1 mg/kg)

Comparison

Pentobarbital (8 mg/kg) vs Baseline in dogs with and without endotoxemia

Design

Preclinical

Authors

MHMatti HalinenUniversity of Eastern Finland MHM. O. K. HakumäkiUniversity of Helsinki HSH. S. S. SarajasUniversity of Helsinki

Discussion

Member takes

Implication

Pentobarbital may confound autonomic measurements in canine models; leaves open translation to endotoxemia or clinical anesthesia.

Key Points

To determine the initial effects of pentobarbital on autonomic efferent and afferent discharge rates and cardiovascular dynamics in dogs with and without endotoxemia.
Evaluated 26 dogs under morphine-chloralose anesthesia administered pentobarbital (8 mg/kg).
Administered Escherichia coli endotoxin (1 mg/kg) to half of the animals prior to pentobarbital infusion.
Recorded postganglionic cervical vagal and cardiac sympathetic efferentation, baroreceptor activity, and hemodynamic parameters.
Postganglionic cervical vagal efferentation and cardiac sympathetic efferentation decreased in all dogs following pentobarbital administration.
Endotoxin-treated dogs exhibited marked decreases in heart rate and aortic pressure, whereas non-endotoxin dogs showed increased heart rate, loss of respiratory arrhythmia, and a slight reduction in aortic pressure.
Aortic arch baroreceptor activity decreased across subjects, while left atrial B-type receptor activity and filling pressures showed no significant changes.

Structured PICO

Does pentobarbital affect autonomic efferent and afferent discharge rates in dogs with or without endotoxemia?

Population

26 dogs under morphine-chloralose anesthesia, half given endotoxin E. coli (1 mg/kg)

Intervention

Pentobarbital (8 mg/kg)

Comparator

Baseline (before pentobarbital) in dogs with and without endotoxemia

Outcome

Autonomic efferent and afferent discharge ratessurrogate

Pentobarbital exerts both sympatholytic and vagolytic effects, impairing cardiovascular control mechanisms, which should be considered when using it in cardiovascular research.

Cite This Study

Halinen et al. (1978) studied this question.

synapsesocial.com/papers/6a716a92e5469ee92be1f575 https://doi.org/10.1111/j.1748-1716.1978.tb06263.x

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Suppression of autonomic postganglionic discharges by pentobarbital in dogs, with or without endotoxemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Suppression of autonomic postganglionic discharges by pentobarbital in dogs, with or without endotoxemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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