March 1, 1975Circulation ResearchOpen Access

Static pressure-flow relation in the total systemic vascular bed of the dog and its modification by the baroreceptor reflex.

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

15 dogs (12 with a perfusion pump interposed at the vena-caval-right atrial junction, 3 closed-chest dogs)

Intervention

Abrogation of the baroreceptor reflex via section of the sinovagal nerves, administration of hexamethonium (30 mg/kg, iv) and norepinephrine (3-5 mug/kg min-1, iv), or both

Comparator

Intact baroreceptor reflex (baseline before abrogation)

Outcome

Static pressure-flow relation (relation between mean arterial blood pressure and mean aortic flow)surrogate

The conventional practice of calculating total peripheral resistance as pressure divided by flow involves only a small error in moderately sub- and supranormal flow ranges.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports simplified TPR calculation at moderate flows; leaves open translation from this animal model to humans.

Cite This Study

Sagawa et al. (1975) studied this question.

synapsesocial.com/papers/6a83e7bef4298de60b3c37ee https://doi.org/10.1161/01.res.36.3.406

View Full Paper

Ask AI

Bookmark

Static pressure-flow relation in the total systemic vascular bed of the dog and its modification by the baroreceptor reflex.

Structured PICO

Discussion

Implication

Cite This Study

Static pressure-flow relation in the total systemic vascular bed of the dog and its modification by the baroreceptor reflex.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider