Key result
In anesthetized dogs, less than half of the compensation for hemorrhage during the first 5 minutes came from reflex venoconstriction, with most compensation from passive viscoelastic creep.
Population
Chloralose-urethane anesthetized dogs
Comparison
Randomized changes in blood volume of 0 to ± 30%… vs Control state (reflexes intact)
Design
Preclinical, randomized changes in blood volume
Follow-up
5 minutes
Authors
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Questions reflex-centric models of early hemorrhage compensation; leaves open passive mechanisms' role in clinical translation.
In a canine model, compensation for hemorrhage during the first 5 minutes is primarily driven by passive viscoelastic creep and fluid shifts rather than reflex venoconstriction.
DREES et al. (1974) studied this question. Changes in blood volume vs. Control volume / ganglionic blockade vs reflexes intact was evaluated on Mean circulatory pressure (PMC) and effective total vascular compliance. In anesthetized dogs, less than half of the compensation for hemorrhage during the first 5 minutes came from reflex venoconstriction, with most compensation from passive viscoelastic creep.
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