Reflex Control of the Systemic Venous Bed
Population
Anesthetized, open-chest dogs on cardiopulmonary bypass and intact, unanesthetized human subjects
Design
Other
Authors
Discussion
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Member takes
Implication
Venous tone modulation merits consideration in hemodynamic assessment; leaves open targeted interventions pending clinical validation.
Structured PICO
P
Population
Anesthetized, open-chest dogs on cardiopulmonary bypass and intact, unanesthetized human subjects
I
Intervention
Neural and humoral stimuli including norepinephrine, epinephrine, trimethaphan, hypoxia, hypercapnia, and blockade with guanethidine and reserpine
O
Outcome
Changes in venous tone (venoconstriction or venodilatation)surrogate
The systemic venous bed is actively regulated by neural and humoral mechanisms, playing a critical role in determining cardiac output and arterial pressure.
Cite This Study
Braunwald et al. (1963) studied this question.