Role of cardiac, pulmonary, and carotid mechanoreceptors in the control of hind-limb and renal circulation in dogs.
Key result
Interruption of cardiac and pulmonary vagal traffic decreased hind-limb blood flow by 23% and 21%, and renal blood flow by 23% and 33%, respectively, during normocapnia in dogs.
Population
Anesthetized dogs with sinoaortic denervation, and closed-chest dogs with aortic nerves sectioned and…
Comparison
Interruption of afferent vagal nerve traffic and… vs Intact vagal traffic/baseline conditions
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Findings in dogs suggest stronger renal protection by cardiopulmonary receptors; leaves open translation to human baroreflex physiology.
Structured PICO
P
Population
Anesthetized dogs with sinoaortic denervation or closed-chest dogs with aortic nerves sectioned, studied to evaluate reflex control of hind-limb and renal resistance vessels.
I
Intervention
Interruption of afferent vagal nerve traffic (cardiac and pulmonary vagal block) and combined withdrawal of carotid and cardiopulmonary inhibition
C
Comparator
Intact vagal traffic/baseline conditions (during normocapnia, hypercapnia, normovolemia, and hypervolemia)
O
Outcome
Changes in hind-limb blood flow and renal blood flowsurrogate
Cardiopulmonary receptors oppose vasoconstriction due to carotid hypotension more effectively in the kidney than in the hind limb in dogs.
Cite This Study
Mancia et al. (1975) studied Anesthetized dogs with sinoaortic denervation. Interruption of afferent vagal nerve traffic vs. Intact vagal traffic was evaluated on Hind-limb and renal blood flow. Interruption of cardiac and pulmonary vagal traffic decreased hind-limb blood flow by 23% and 21%, and renal blood flow by 23% and 33%, respectively, during normocapnia in dogs.