Key result
Interruption of cardiac and pulmonary vagal traffic decreased hind-limb blood flow by 23% and 21%, and renal blood flow by 23% and 33%, respectively, during normocapnia in dogs.
Cardiopulmonary receptors oppose vasoconstriction due to carotid hypotension more effectively in the kidney than in the hind limb in dogs.
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Findings in dogs suggest stronger renal protection by cardiopulmonary receptors; leaves open translation to human baroreflex physiology.
Mancia et al. (1975) studied Anesthetized dogs with sinoaortic denervation. Interruption of afferent vagal nerve traffic vs. Intact vagal traffic was evaluated on Hind-limb and renal blood flow. Interruption of cardiac and pulmonary vagal traffic decreased hind-limb blood flow by 23% and 21%, and renal blood flow by 23% and 33%, respectively, during normocapnia in dogs.
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