Key result
Systemic hypoxia markedly potentiated the reflex renal constriction caused by the baroreflex, increasing renal perfusion pressure by 87 mmHg more than during normoxia.
Why the study?
Does systemic hypoxia alter the vascular responses to the carotid baroreflex in anesthetized dogs?
Population
Anesthetized, vagotomized, artificially ventilated dogs
Comparison
Systemic hypoxia during bilateral carotid… vs Normoxia during bilateral carotid occlusion
Design
Preclinical
Authors
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No immediate clinical implications from canine data; leaves open human relevance of hypoxia-potentiated baroreflex constriction.
Does systemic hypoxia alter the vascular responses to the carotid baroreflex in anesthetized dogs?
Systemic hypoxia significantly potentiates reflex renal constriction caused by the baroreflex via carotid chemoreceptor afferent input.
Pelletier et al. (1975) studied this question. Systemic hypoxia vs. Normoxia (air and O2 mixture) was evaluated on Vascular responses to the carotid baroreflex (increase in mean aortic pressure and renal perfusion pressure). Systemic hypoxia markedly potentiated the reflex renal constriction caused by the baroreflex, increasing renal perfusion pressure by 87 mmHg more than during normoxia.
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