Key result
The use of acetylcholine to arrest the heart in reflex-blocked dogs demonstrated a nonlinear total body pressure-volume relationship without altering hemodynamics or pulmonary function.
Acetylcholine can be safely used to arrest the heart for measuring mean circulatory filling pressure in dogs without altering baseline hemodynamics or pulmonary function.
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May facilitate mean circulatory filling pressure assessment in canine models; leaves human translation open.
Lee et al. (1988) studied Total vascular capacitance measurement (n=12). Acetylcholine to arrest the heart during controlled hemorrhage and volume loading vs. Baseline was evaluated on Mean circulatory filling pressure (MCFP) and pressure-volume relationship. The use of acetylcholine to arrest the heart in reflex-blocked dogs demonstrated a nonlinear total body pressure-volume relationship without altering hemodynamics or pulmonary function.
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