Why the study?
How do hexamethonium and norepinephrine alter systemic vascular volume and venous return in dogs?
Population
Dogs with a diaphragm pump substituted for the left ventricle (complete left ventricular by-pass)
Design
Preclinical
Authors
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No clinical implications from canine data; leaves open sympathetic regulation of vascular volume in humans.
How do hexamethonium and norepinephrine alter systemic vascular volume and venous return in dogs?
The sympathetic nervous system plays a key role in adjusting total vascular volume and venous return, which in turn alters cardiac output.
Rose et al. (1957) studied this question.
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