Why the study?
Does phenylephrine alter arterial and venous resistance and compliance in anesthetized dogs?
Does phenylephrine alter arterial and venous resistance and compliance in anesthetized dogs?
In a canine model, phenylephrine significantly increases arterial resistance with minimal effects on venous resistance, leading to a slight decrease in venous return and cardiac output.
SUMMARY The influence of phenylephrine (an α-adrenoreceptor agonist) on the arterial and venous systems of the systemic circulation was studied in 10 anesthetized dogs during a right ventricular bypass procedure. Phenylephrine (1 μg·kg -1 of body weight·min -1 ) produced a significant ( P < 0.001) increase in arterial resistance, no change in venous resistance, and a mild decrease in venous compliance. Seemingly in the clinically normal dog, a dose of phenylephrine sufficient to double total peripheral resistance will redistribute a small amount of blood volume from the venous to arterial systems with a slight decrease in venous return and concomitant attentuation of cardiac output.
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Sheldon et al. (1983) studied this question.
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