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January 1, 1977The Japanese Journal of PhysiologyOpen Access

Effect of Cardiac Output on Circulatory Blood Volume

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Key result

Changes in cardiac output induce passive changes in blood volume that are as large as active reflexic changes, with the majority of the change occurring in the systemic circulation.

Population

Anesthetized dogs, weighing 8.0-13.0 kg.

Comparison

Stepwise changes in cardiac output by +/- 25% or… vs Intact reflexic state versus areflexic state.

Design

Preclinical

Follow-up

5 minutes

Authors

YNYoshinobu NumaoUniversity of TsukubaJIJuro IriuchijimaCMIC Group (Japan)

Discussion

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Implication

Should not yet inform clinical volume management; hypothesis-generating for integrated passive-reflex circulatory control.

Structured PICO

P
Population
24 anesthetized dogs undergoing experimental manipulation of cardiac output via pump perfusion to measure changes in circulatory blood volume.
I
Intervention
Stepwise changes in cardiac output (pump flow) by +/- 25% or 50% of control, and reduction of flow through right heart and lungs by 50%.
C
Comparator
Intact reflexic state versus areflexic state (induced by hexamethonium and norepinephrine infusion).
O
Outcome
Change in circulatory blood volume (measured via reservoir volume) 5 minutes after stepwise changes in cardiac output.surrogate

In a canine model, passive changes in blood volume following changes in cardiac output are as large as active reflexic changes, with the majority occurring in the systemic circulation.

Limitations

  • The experimental preparation utilized an open circulatory loop with constant outflow venous pressure, which differs from a natural closed circulatory system.
  • The study was conducted in anesthetized animals subjected to surgical trauma, which may affect reflex responses.
  • Preparation used an open circulatory loop at the caval veins with constant outflow venous pressure, differing from a natural closed circulatory system.

Cite This Study

Numao et al. (1977) studied Healthy (anesthetized dogs) (n=24). Changes in cardiac output (pump flow) vs. Control flow (80 ml/min/kg) was evaluated on Change in circulatory blood volume. Changes in cardiac output induce passive changes in blood volume that are as large as active reflexic changes, with the majority of the change occurring in the systemic circulation.

synapsesocial.com/papers/6a23a64355bd20cf6fa615d3https://doi.org/10.2170/jjphysiol.27.145
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Also Consider

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  1. 1Control of Total Systemic Vascular Capacity by the Carotid Sinus Baroreceptor Reflex1973 · 229 citations
  2. 2Influence of Carotid Baroreceptors and Vasoactive Drugs on Systemic Vascular Volume and Venous Distensibility1961 · 65 citations
  3. 3Pressure-Volume Curves of the Arterial and Venous Systems in Live Dogs1956 · 67 citations
  4. 4The Relationship between Active Constriction and Passive Recoil of the Veins at Various Distending Pressures1967 · 104 citations
  5. 5Total Systemic Vascular Compliance Measured as Incremental Volume-Pressure Ratio1971 · 93 citations