Why the study?
Does opening large A-V fistulas affect cardiac output in areflex dogs compared to dogs with intact reflexes?
Population
20 dogs (10 made areflex by administration of total anesthesia, 10 with intact reflexes)
Comparison
Opening large A-V fistulas with flows equal to… vs Dogs with intact reflexes
Design
Preclinical
Follow-up
15-30 seconds
Authors
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Nonreflex mechanisms sustain most CO rise after A-V fistula in dogs; extends compensatory physiology but leaves human translation open.
Does opening large A-V fistulas affect cardiac output in areflex dogs compared to dogs with intact reflexes?
The circulation can compensate for most A-V fistula flow through nonreflex mechanisms such as increased venous return and Starling's principle, even in the complete absence of circulatory reflexes.
Guyton et al. (1961) studied this question.
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