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March 31, 1958American Journal of Physiology-Legacy Content

Effect of Arteriovenous Fistula on Mean Arterial Blood Pressure, Coronary Blood Flow, Cardiac Output, Oxygen Consumption, Work and Efficiency

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Why the study?

Does acute arteriovenous fistulae alter coronary blood flow and cardiac efficiency in anesthetized dogs?

Population

anesthetized dogs

Design

Preclinical

Follow-up

acute

Authors

RWRené WégriaSaint Louis UniversityJNJiro NakanoKansai Medical UniversityJMJ C McGiffNewYork–Presbyterian Hospital

Discussion

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Implication

Preclinical data warrant caution against clinical extrapolation; leaves open mechanistic questions on efficiency in high-output states.

Structured PICO

Does acute arteriovenous fistulae alter coronary blood flow and cardiac efficiency in anesthetized dogs?

P
Population
anesthetized dogs
I
Intervention
acute arteriovenous fistulae sufficient to increase cardiac output by 16 to 130%
O
Outcome
coronary blood flow, mean arterial blood pressure, cardiac work, oxygen consumption, and cardiac efficiencysurrogate

In a canine model, acute arteriovenous fistulae increase coronary blood flow and cardiac efficiency despite reducing mean arterial blood pressure.

Cite This Study

Wégria et al. (1958) studied this question.

synapsesocial.com/papers/6a96347de2c87aea1dd22f73https://doi.org/10.1152/ajplegacy.1958.193.1.147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of arteriovenous fistula on systemic and pulmonary circulations1964 · 38 citations
  2. 2Effect of ventricular tachycardia and arteriovenous fistula on catecholamines blood level1961 · 23 citations
  3. 3The effect of chronic cardiac volume overload on regional myocardial blood flow in the dog1975 · 7 citations
  4. 4New Porcine Model of Arteriovenous Fistula Documents Increased Coronary Blood Flow at the Cost of Brain Perfusion2022 · 5 citations
  5. 5A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model2023 · 2 citations