Key result
Non-surgical arteriovenous fistula creation in pigs boosts cardiac output ~31% but lowers brain oxygenation.
Why the study?
The specific impact of arteriovenous fistulas on competing organ perfusion had not been elucidated, and a simple animal model was needed to analyze acute hemodynamic changes.
Does the creation of a non-surgical arteriovenous fistula alter systemic hemodynamics and organ perfusion in a porcine model?
Population
Domestic female pigs weighing 62.6 ± 5.2 kg
Comparison
Hemodynamic changes following arteriovenous fistula creation
Design
Preclinical animal model study
Authors
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AVF creation in pigs trades cerebral perfusion for higher cardiac output; leaves open human translation.
Does the creation of a non-surgical arteriovenous fistula alter systemic hemodynamics and organ perfusion in a porcine model?
Absolute Event Rate: 9.19% vs 7.02%
p-value: p=0.0001
A novel non-surgical porcine model of arteriovenous fistula demonstrates that increased cardiac output and coronary blood flow occur at the expense of brain and muscle perfusion.
Valeriánová et al. (2022) studied Healthy swine (Arteriovenous fistula model) (n=11). Non-surgical arteriovenous fistula (AVF) creation vs. Baseline (before AVF opening) was evaluated on Cardiac output (L/min) (p=0.0001). Creation of a non-surgical arteriovenous fistula in a porcine model significantly increased cardiac output from 7.02 to 9.19 L/min while decreasing carotid artery flow and brain tissue oxygenation.
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