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September 1, 1986AJP Heart and Circulatory Physiology

Total vascular pressure-volume relationship in conscious rats with chronic heart failure

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Why the study?

Does chronic heart failure alter venous capacitance and effective vascular compliance in conscious rats?

Population

Conscious rats with chronic heart failure, sham-operated rats, and normal rats.

Comparison

Induction of chronic heart failure via coronary… vs Sham-operated and normal rats.

Design

Preclinical

Follow-up

3 weeks

Authors

RGR. GaySWSteven WoolMPM. Paquin

Discussion

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Overview

Supports reduced venous compliance in rodent HF models; leaves open translation to human capacitance and therapy.

Structured PICO

Does chronic heart failure alter venous capacitance and effective vascular compliance in conscious rats?

P
Population
Conscious rats with chronic heart failure (myocardial infarction and LV end-diastolic pressure > 15 mmHg, n=11), sham-operated rats (n=9), and normal rats (n=6).
I
Intervention
Induction of chronic heart failure via coronary ligation (assessed at 3 weeks) and administration of hexamethonium chloride.
C
Comparator
Sham-operated and normal rats.
O
Outcome
Mean circulatory filling pressure (MCFP), blood volume, and effective vascular compliance.surrogate

Chronic heart failure in a rat model is associated with decreased venous capacitance due to a reduction in effective vascular compliance, without significant changes in unstressed vascular volume.

Cite This Study

Gay et al. (1986) studied this question.

synapsesocial.com/papers/6a8592ad4f2eb4dbc91e6334https://doi.org/10.1152/ajpheart.1986.251.3.h483
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