Population
27 male adult Wistar rats
Comparison
Coronary ligation to induce chronic heart failure vs Sham surgery
Design
Preclinical, randomized
Follow-up
10 weeks
Key result
Chronic heart failure induced by myocardial infarction in rats significantly reduced respiratory system compliance and increased left ventricular end-diastolic pressure (32 vs 4 mmHg, P<0.01).
Authors
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Rat HF model links elevated LVEDP to reduced compliance; hypothesis-generating for human cardiopulmonary interactions.
RCT (n=27)
randomized
Absolute Event Rate: 32% vs 4%
p-value: p=<0.01
In a rat model of myocardial infarction, chronic heart failure significantly impairs respiratory mechanics and hemodynamics, correlating with the degree of pulmonary edema.
Pacheco et al. (2016) conducted an RCT in Chronic heart failure (CHF) following myocardial infarction (n=27). Coronary ligation (CHF model) vs. Sham surgery was evaluated on Left ventricular end-diastolic pressure (mmHg) (p=<0.01). Chronic heart failure induced by myocardial infarction in rats significantly reduced respiratory system compliance and increased left ventricular end-diastolic pressure (32 vs 4 mmHg, P<0.01).
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