Why the study?
Does chronic heart failure alter breathing pattern, ventilatory drive, and respiratory muscle strength compared to post-myocardial infarction patients without left ventricular dysfunction?
Population
45 male inpatients with chronic heart failure and 22 sex-matched post-myocardial infarction patients without…
Design
Cross-sectional
Key result
Chronic heart failure was associated with significantly increased neural ventilatory drive (1.86 vs 1.4 cmH2O) and reduced maximal inspiratory pressure (79 vs 104 cmH2O) compared to controls.
Authors
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CHF may alter ventilatory drive and muscle strength by severity; hypothesis-generating for respiratory mechanics in advanced disease.
Observational (n=67)
Does chronic heart failure alter breathing pattern, ventilatory drive, and respiratory muscle strength compared to post-myocardial infarction patients without left ventricular dysfunction?
Absolute Event Rate: 1.86% vs 1.4%
Chronic heart failure induces changes in neural ventilatory drive and respiratory muscle strength that correlate with the severity of the disease.
Ambrosino et al. (1994) conducted an observational in Chronic heart failure (n=67). Chronic heart failure vs. Post myocardial infarction without left ventricular dysfunction was evaluated on Neural drive assessed by mouth occlusion pressure (P0.1). Chronic heart failure was associated with significantly increased neural ventilatory drive (1.86 vs 1.4 cmH2O) and reduced maximal inspiratory pressure (79 vs 104 cmH2O) compared to controls.
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