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January 1, 2001Cardiovascular ResearchOpen Access

Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates

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Population

144 guinea-pigs (n=66 with heart failure induced by banding of the ascending aorta, n=78 sham control)

Comparison

Heart failure induced by banding of the… vs Sham control operation

Design

Preclinical

Follow-up

150+/-8 days post-operation

Authors

WHWen‐Yi Huang

Discussion

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Overview

Hypothesis-generating for adaptive protection against edema in chronic HF; human studies needed before clinical relevance.

Structured PICO

P
Population
144 guinea-pigs (n=66 with heart failure induced by banding of the ascending aorta, n=78 sham control)
I
Intervention
Heart failure induced by banding of the ascending aorta
C
Comparator
Sham control operation
O
Outcome
Pulmonary capillary filtration, vascular resistances and morphologysurrogate

Pulmonary adaptation to chronic heart failure involves vascular and alveolar remodeling that reduces capillary filtration, potentially mediating resistance to pulmonary edema.

Cite This Study

Wen‐Yi Huang (2001) studied this question.

synapsesocial.com/papers/6a064cab0924dc877016d8d0https://doi.org/10.1016/s0008-6363(00)00223-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig1999 · 11 citations
  2. 2Pulmonary Microvascular Permeability1995 · 111 citations
  3. 3Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs1984 · 56 citations
  4. 4Peripheral Vascular Alterations During Experimental Heart Failure in the Rat1995 · 25 citations
  5. 5Pulmonary vascular response to angiotensin II in canine pacing-induced heart failure1996 · 25 citations