Why the study?
Does chronic elevation of pulmonary microvascular pressure in chronic heart failure reduce bi-directional pulmonary fluid flux?
Population
Isolated rat lungs 7 weeks following left coronary artery ligation and patients presenting with acute…
Comparison
Chronic heart failure vs No chronic heart failure
Design
Preclinical
Follow-up
7 weeks (rats), 24 hours (patients)
Key result
Chronic heart failure was associated with reduced plasma volume expansion at 24 hours in patients with acute pulmonary edema (P=0.03), indicating decreased bi-directional pulmonary fluid flux.
Authors
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May suggest adaptive barrier defense in chronic HF; leaves open effects on edema resolution and need for human trials.
Observational (n=90)
Does chronic elevation of pulmonary microvascular pressure in chronic heart failure reduce bi-directional pulmonary fluid flux?
p-value: p=0.03
Chronic heart failure induces an adaptive decrease in bi-directional fluid flux at the alveolar-capillary barrier, which defends against alveolar flooding but may delay the resolution of pulmonary edema.
Dixon et al. (2012) conducted an observational in Chronic heart failure and acute pulmonary oedema (n=90). Chronic heart failure vs. No history of chronic heart failure was evaluated on Plasma volume expansion at 24 h (p=0.03). Chronic heart failure was associated with reduced plasma volume expansion at 24 hours in patients with acute pulmonary edema (P=0.03), indicating decreased bi-directional pulmonary fluid flux.
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