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July 1, 2006AJP Lung Cellular and Molecular Physiology

AFR in control rats was 0.49 +/- 0.02 ml/h and increased by approximately 40% (0.69 +/- 0.03 ml/h) in rats with chronic CHF (P < 0.001).

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Why the study?

Does chronic compensated CHF induced by aorto-caval fistula increase alveolar fluid reabsorption in Sprague-Dawley male rats?

Population

Sprague-Dawley male rats

Comparison

Creation of an aorto-caval fistula to induce… vs Control rats

Design

Preclinical

Follow-up

7 days

Authors

ZAZaher S. AzzamYAYochai AdirLWLynn C. Welch

Discussion

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Overview

Chronic compensated CHF increases alveolar fluid reabsorption in rats; leaves open translation to human pulmonary edema protection.

Structured PICO

Does chronic compensated CHF induced by aorto-caval fistula increase alveolar fluid reabsorption in Sprague-Dawley male rats?

P
Population
Sprague-Dawley male rats
I
Intervention
Creation of an aorto-caval fistula (ACF) to induce chronic congestive heart failure (CHF)
C
Comparator
Control rats
O
Outcome
Alveolar fluid reabsorption (AFR) at 7 dayssurrogate

Chronic compensated heart failure in a rat model increases alveolar fluid reabsorption, likely as a protective mechanism against alveolar flooding mediated by increased norepinephrine.

Cite This Study

Azzam et al. (2006) studied this question.

synapsesocial.com/papers/6a78fe076971db5bdd6743c1https://doi.org/10.1152/ajplung.00180.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic Elevation of Pulmonary Microvascular Pressure in Chronic Heart Failure Reduces Bi-Directional Pulmonary Fluid Flux2012 · 21 citations
  2. 2Hormonal determinants of sodium excretion in rats with experimental high-output heart failure1988 · 66 citations
  3. 3Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep1999 · 56 citations
  4. 4Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987
  5. 5Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987 · 6 citations