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March 1, 1993AJP Heart and Circulatory Physiology

Effects of chronic heart failure on skeletal muscle vascular transport capacity of rats

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Why the study?

Does chronic heart failure alter skeletal muscle vascular transport capacity in rats?

Population

14 rats

Comparison

Chronic heart failure induced by myocardial… vs Sham operation

Design

Preclinical

Follow-up

8-9 months post-MI

Authors

RMR. M. McAllisterUniversity of MissouriMLM. Harold LaughlinUniversity of North TexasTMTimothy I. MuschHeart Failure & Transplant

Discussion

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Implication

No immediate implications for human HF care; leaves open fiber-type selective vascular mechanisms for further study.

Structured PICO

Does chronic heart failure alter skeletal muscle vascular transport capacity in rats?

P
Population
14 rats (n=10 with surgically produced large myocardial infarction via left main coronary artery ligation, n=4 sham-operated controls)
I
Intervention
Chronic heart failure induced by myocardial infarction
C
Comparator
Sham operation
O
Outcome
Vascular transport capacity of the hindquarters (including perfusion pressures, capillary pressures, capillary filtration coefficients, precapillary and postcapillary vascular resistances, and flow)surrogate

Chronic heart failure selectively reduces the vascular flow capacity of skeletal muscle comprised primarily of high oxidative fibers in a rat model.

Cite This Study

McAllister et al. (1993) studied this question.

synapsesocial.com/papers/6a8c581e808303650eee239bhttps://doi.org/10.1152/ajpheart.1993.264.3.h686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal muscle blood flow abnormalities in rats with a chronic myocardial infarction: rest and exercise1992 · 157 citations
  2. 2Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure1999 · 88 citations
  3. 3Effects of chronic heart failure on skeletal muscle capillary hemodynamics at rest and during contractions2003 · 131 citations
  4. 4Skeletal muscle oxidative capacity and exercise tolerance in rats with heart failure2001 · 19 citations
  5. 5Vascular rarefaction in peripheral skeletal muscle after experimental heart failure2003 · 29 citations