Why the study?
Does experimental heart failure induced by coronary artery ligation reduce vascular density in peripheral skeletal muscle in New Zealand White rabbits?
Population
22 New Zealand White rabbits (experimental model of CHF)
Comparison
Congestive heart failure induced by coronary… vs Sham surgery without coronary artery ligation
Design
Preclinical
Follow-up
up to 21 days
Authors
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May link skeletal muscle rarefaction to exercise intolerance in experimental CHF; leaves open relevance to patients.
Does experimental heart failure induced by coronary artery ligation reduce vascular density in peripheral skeletal muscle in New Zealand White rabbits?
Experimental heart failure leads to vascular rarefaction and endothelial apoptosis in peripheral skeletal muscle, providing a potential mechanism for exercise intolerance in CHF.
Nusz et al. (2003) studied this question.
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