Key result
Acute exercise upregulated skeletal muscle VEGF mRNA equally in patients with chronic heart failure and controls, revealing normal basal levels and appropriate response.
Why the study?
Does acute exercise upregulate skeletal muscle VEGF mRNA in patients with chronic heart failure compared to controls?
Population
13 participants (7 patients with chronic heart failure and 6 controls)
Comparison
30 min of single-leg knee-extensor exercise at… vs Healthy controls and rested leg
Design
Cross-sectional
Authors
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Preserved acute VEGF response in HF supports exercise as stimulus; leaves open long-term angiogenic or outcome effects.
Case-Control (n=13)
Does acute exercise upregulate skeletal muscle VEGF mRNA in patients with chronic heart failure compared to controls?
Patients with chronic heart failure retain the ability to normally upregulate skeletal muscle VEGF mRNA in response to acute exercise despite having lower muscle blood flow and oxygen uptake.
Esposito et al. (2010) conducted a case-control in Chronic heart failure (n=13). Chronic heart failure vs. Healthy controls was evaluated on Resting and post-exercise muscle vascular endothelial growth factor (VEGF) mRNA levels. Acute exercise upregulated skeletal muscle VEGF mRNA equally in patients with chronic heart failure and controls, revealing normal basal levels and appropriate response.
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