January 1, 2007Circulation JournalOpen Access

Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure

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Why the study?

Does symptom-limited leg exercise alter forearm vascular resistance and blood flow redistribution in patients with mild chronic heart failure compared to healthy subjects?

Population

14 consecutive patients with mild chronic heart failure and 10 healthy sedentary volunteers.

Comparison

Symptom-limited multistage-ergometer leg exercise vs Healthy sedentary volunteers undergoing the same…

Design

Cross-sectional

Authors

YCYoshifumi ChibaImperial Household Agency KMKazuhira MaeharaFukushima Medical University HYHiroyuki YaoitaFukushima Medical University

Discussion

Member takes

Implication

Impaired redistribution may limit exercise capacity in mild CHF; hypothesis-generating for vascular-targeted interventions.

Structured PICO

Does symptom-limited leg exercise alter forearm vascular resistance and blood flow redistribution in patients with mild chronic heart failure compared to healthy subjects?

Population

14 consecutive patients with mild chronic heart failure (NYHA functional class I or II, LVEF <50%, mean age 55±18, 12 male) and 10 healthy sedentary volunteers (mean age 47±8, 10 male).

Intervention

Symptom-limited multistage-ergometer leg exercise (supine bicycle ergometer)

Comparator

Healthy sedentary volunteers undergoing the same exercise protocol

Outcome

Forearm vascular resistance (FVR), cardiac index (CI), systemic vascular resistance index (SVRI), and oxygen uptake (VO2) during exercisesurrogate

In patients with mild chronic heart failure, the redistribution of blood flow from non-exercising tissues to working skeletal muscles during exercise is blunted due to increased resting vascular tone, contributing to reduced exercise capacity.

Limitations

Investigated vasoconstrictive response only in non-exercising skeletal muscles of the forearm, which might not reflect all non-exercising vascular beds.
Patients had mild CHF, so relationships may not apply to moderate to severe CHF.
Correlations among variables were evaluated in all subjects together due to small population.
Angiotensin II and endothelin-1 levels were measured in the resting state only.
Did not measure absolute amounts of blood flow redistributed from non-exercising to exercising muscles.
Fasted state might change energy substrate utilization during exercise.
Lactate concentrations from non-exercising forearm vein might not reflect working skeletal muscle lactate without time delay.

Cite This Study

Chiba et al. (2007) studied this question.

synapsesocial.com/papers/6a77c283137c7dcc81be0bec https://doi.org/10.1253/circj.71.922

Topics

Heart failure HFrEF treatment

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Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider