Key result
One-legged knee extensor endurance training increased peak power and peak oxygen uptake by ~10-16% in the trained leg versus the control leg, with equal responses across CHF, CAD, and healthy groups.
Why the study?
Does one-legged knee extensor endurance training elicit a normal skeletal muscle training response in CHF patients compared to CAD patients and healthy subjects?
Does one-legged knee extensor endurance training elicit a normal skeletal muscle training response in CHF patients compared to CAD patients and healthy subjects?
Skeletal muscle in CHF patients, despite being more fatigable at baseline, responds equally well to endurance training as that of CAD patients and healthy subjects.
May support targeted leg training in CHF rehab; hypothesis-generating before practice change or outcome trials.
Congestive heart failure (CHF) patients experience reduced muscle fatigue resistance and exercise capacity. The aim of this study was to assess whether skeletal muscle in CHF patients has a normal training response compared to healthy subjects. We compared the effect of one‐legged knee extensor (1‐KE) endurance training in CHF patients ( n =10), patients with coronary artery disease (CAD, n =9) and healthy subjects ( n =13). The training response was evaluated by comparing trained leg and control leg after the training period. The fall in peak torque during 75 maximal 1‐KE isokinetic contractions revealed that CHF patients were less fatigue resistant than healthy subjects in the control leg, but not in the trained leg. Peak power and peak oxygen uptake during dynamic 1‐KE exercise was ~10–16% higher in trained leg than control leg. This training response was not significant different between groups. Muscle biopsies of vastus lateralis showed that fibre type composition was not different between trained leg and control leg. Capillary density was 6.5% higher in trained leg than control leg when all groups were pooled. In conclusion, the more fatigable skeletal muscle of CHF patients responds equally to endurance training compared to skeletal muscle of CAD patients and healthy subjects.
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Slettaløkken et al. (2011) studied Congestive heart failure (n=32). One-legged knee extensor (1-KE) endurance training vs. Control leg (untrained) was evaluated on Peak power and peak oxygen uptake during dynamic 1-KE exercise (~10-16% higher). One-legged knee extensor endurance training increased peak power and peak oxygen uptake by ~10-16% in the trained leg versus the control leg, with equal responses across CHF, CAD, and healthy groups.
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