What question did this study set out to answer?

To determine whether localized knee extensor exercise training improves skeletal muscle exercise capacity and reverses muscle abnormalities in patients with moderate chronic heart failure.

July 1, 1996Clinical CardiologyOpen Access

Markedly improved skeletal muscle function with local muscle training in patients with chronic heart failure

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Why the study?

Does local exercise training improve exercise capacity and skeletal muscle function in patients with moderate chronic heart failure?

Key Points

To determine whether localized knee extensor exercise training improves skeletal muscle exercise capacity and reverses muscle abnormalities in patients with moderate chronic heart failure.
Randomized trial allocating 14 patients with chronic heart failure (mean age 58 ± 3 years, ejection fraction 28 ± 4%) to 8 weeks (3 sessions/week) of two-legged (Group 2L, n=7) or one-legged (Group 1L, n=7) knee extensor training versus a non-training control group (n=7, mean age 62 ± 3 years, ejection fraction 27 ± 3%).
Evaluated peak oxygen uptake (VO2), two-legged endurance capacity, muscle strength, and quadriceps femoris citrate synthase enzyme activity before and after intervention.
Two-legged knee extensor endurance capacity increased by an average of 40–50% in both the 2L and 1L training groups (p < 0.01), with no change observed in the control group.
Skeletal muscle citrate synthase activity increased by 25–35% across both training groups (p < 0.01), while muscle strength increased by 16% in the 2L group only (p < 0.05) and peak VO2 remained unchanged.

Structured PICO

Does local exercise training improve exercise capacity and skeletal muscle function in patients with moderate chronic heart failure?

Population

21 patients with moderate chronic heart failure (14 in training groups, 7 in control group). Training group: age 58 +/- 3 years, ejection fraction 28 +/- 4%. Control group: age 62 +/- 3 years, ejection fraction 27 +/- 3%.

Intervention

Local exercise training three times a week for 8 weeks, either as simultaneous two-legged knee extensor training for 15 min at 65-75% of VO2 max (Group 2L, n=7) or one-legged dynamic knee extensor work for 15 min per leg at 35% of VO2 max (Group 1L, n=7).

Comparator

Nontraining control group (n=7).

Outcome

Peak VO2 of two-legged knee extensor exercise, two-legged endurance, strength, and citrate synthase (CS) activity in the quadriceps femoris muscle.surrogate

Local muscle training significantly improves skeletal muscle endurance and oxidative capacity in patients with moderate chronic heart failure, counteracting deconditioning.

Discussion

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Implication

Supports localized knee extensor training in moderate HF rehab; extends evidence for muscle-specific interventions reversing deconditioning.

Cite This Study

Gordon et al. (1996) studied this question.

synapsesocial.com/papers/6a78893598f24dbf64bdd246 https://doi.org/10.1002/clc.4960190709

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Implication

Supports localized knee extensor training in moderate HF rehab; extends evidence for muscle-specific interventions reversing deconditioning.

Markedly improved skeletal muscle function with local muscle training in patients with chronic heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Markedly improved skeletal muscle function with local muscle training in patients with chronic heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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