One month of local forearm muscle training in heart failure patients increased PCr resynthesis rate by 48% (P<0.01) and endurance exercise duration by 67% (P<0.01).
Does 1 month of local muscle training improve forearm metabolic responses to exercise in males with heart failure?
Local muscle training partially reverses skeletal muscle metabolic abnormalities in heart failure, suggesting that some of the impairment is due to inactivity.
Effect estimate: 48% increase
p-value: p=<0.01
Using 31P-magnetic resonance spectroscopy during and after exercise, we studied whether forearm metabolic responses to exercise were improved by 1 mo of training in 10 males with heart failure. In the control (untrained) arm, there were no changes in any of the measured variables. In the trained arm, maximal voluntary contraction increased 6% (P = 0.05). During incremental exercise, duration increased 19% (P < 0.05) and submaximal responses improved for pH (6.78 +/- 0.13 pretraining vs. 6.85 +/- 0.17 posttraining; P < 0.01) and PCr/(PCr+Pi) (where PCr is phosphocreatine; 0.48 +/- 0.09 pretraining vs. 0.52 +/- 0.07 posttraining; P < 0.01). The PCr resynthesis rate increased by 48% (P < 0.01), and estimated effective maximal rate of mitochondrial ATP synthesis increased by 37% (P < 0.05). Endurance exercise duration increased by 67% (P < 0.01), and submaximal levels of PCr/(PCr+Pi) (P < 0.05) and pH (P = 0.07) improved. The PCr resynthesis rate (P < 0.01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0.05) also improved. These findings document that impaired oxidative capacity of skeletal muscle can be improved by local muscle training in heart failure, which is compatible with the hypothesis that a part of the abnormality present in heart failure may be due to inactivity.
Stratton et al. (Fri,) conducted a other in Heart failure (n=10). Local muscle training (forearm) vs. Control (untrained) arm was evaluated on Forearm metabolic responses to exercise (PCr resynthesis rate) (48% increase, p=<0.01). One month of local forearm muscle training in heart failure patients increased PCr resynthesis rate by 48% (P<0.01) and endurance exercise duration by 67% (P<0.01).