Why the study?
Does dynamic one- and two-legged knee extensor work affect central and peripheral circulatory responses differently in patients with chronic heart failure compared to healthy controls?
Population
10 patients with chronic heart failure (ejection fraction 26 (9)%) and 12 healthy controls
Comparison
Dynamic one- and two-legged knee extensor work vs Healthy controls performing the same exercise
Design
Cross-sectional
Authors
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Muscle mass activation may influence perfusion in moderate CHF; leaves open mechanisms of exercise intolerance and needs prospective validation.
Does dynamic one- and two-legged knee extensor work affect central and peripheral circulatory responses differently in patients with chronic heart failure compared to healthy controls?
Patients with moderate chronic heart failure can achieve normal peak skeletal muscle perfusion when a small muscle mass is exercised, but perfusion is markedly reduced when a larger muscle mass is activated.
Magnusson et al. (1997) studied this question.
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